Definitions and Selected Literature
Foodomics is a discipline in the field of food and nutrition that applies and integrates comprehensive high-throughput -omics technologies to improve human health, well-being, and nutritional knowledge. Foodomics encompasses the global food domain, including fields such as nutrigenomics. Studies in foodomics may focus on areas such as the mechanisms of different bioactive food components in the body, the quantification of dietary biomarkers to identify different health states, the assessment of food quality and safety, or examination of the body's biological response to different nutritional patterns.
The Food Metabolome
The food metabolome is the part of the human metabolome directly derived from the digestion and biotransformation of foods and their constituents. With over 25,000 compounds known in various foods, and an extensive metabolism of many of them by host enzymes and gut microbiota, the food metabolome is extremely complex, with a composition varying widely according to the diet. This variability constitutes a unique and extremely rich source of information on the human diet, which can be used for pusposes such as accurate monitoring of dietary exposure and identification of foods that influence disease risks.
Dietary biomarkers are specific measurements within the body that accurately reflect the intake of a food constituent or food. These markers are measured in biofluids such as blood and urine, and include natural food constituents such as vitamins and fatty acids, in addition to certain food additives like iodine in milk or food contaminants like polychlorinated biphenyls in fatty fish. Dietary biomarkers can be used measure nutritional status and food intake, to find associations between diet and disease outcomes, and to monitor dietary changes in populations.
A selection of papers on the food metabolome and identification/validation of dietary biomarkers.
Dec 2016 – April 2017
- The translation of lipid profiles to nutritional biomarkers in the study of infant metabolism
- One (small) step towards precision nutrition by use of metabolomics
- The nutritional metabolomics crossroads: how to ensure success for dietary biomarkers
- Metabolic Phenotyping of Diet and Dietary Intake
- Untargeted metabolomic analysis of human serum samples associated with different levels of red meat consumption: A possible indicator of type 2 diabetes?
- A metabolomic study of biomarkers of meat and fish intake
- Metabolomic profiles as reliable biomarkers of dietary composition
- Metabolomics as a tool in the identification of dietary biomarkers
- Detecting Beer Intake by Unique Metabolite Patterns
- Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample
- Urinary 1H Nuclear Magnetic Resonance Metabolomic Fingerprinting Reveals Biomarkers of Pulse Consumption Related to Energy-Metabolism Modulation in a Subcohort from the PREDIMED study
- Lessons on dietary biomarkers from twin studies
- Metabolites Associated With Malnutrition in the Intensive Care Unit Are Also Associated With 28-Day Mortality: A Prospective Cohort Study
- Exposome-Explorer: a manually-curated database on biomarkers of exposure to dietary and environmental factors
- The role of metabolomics in determination of new dietary biomarkers
- Identifying biomarkers of dietary patterns by using metabolomics
- Integrated Analytical and Statistical Two-Dimensional Spectroscopy Strategy for Metabolite Identification: Application to Dietary Biomarkers
- A serum metabolomics-driven approach predicts orange juice consumption and its impact on oxidative stress and inflammation in subjects from the BIONAOS study
- Use of biomarkers to assess fruit and vegetable intake
- Urinary Biomarkers of Whole Grain Wheat Intake Identified by Non-targeted and Targeted Metabolomics Approaches